Xi'an Bioland's industrial ultrasonic homogenizer is purpose-built for 24/7 continuous production. The system uses 20kHz/24kHz acoustic cavitation technology, with power ranging from 250W to 4000W. Grade 5 titanium alloy probes combined with automatic frequency tracking can reduce reaction temperature by 20–30°C and shorten reaction time by up to one-third. Certified to CE, ISO, UL, and SGS, it supports explosion-proof configurations and PLC automatic control, and is widely used in pharmaceuticals, lithium battery slurries, plant extraction, and nanomaterials.
Automatic Frequency Tuning — No Manual Recalibration
The generator tracks resonant frequency in real time, compensating for temperature shifts and viscosity changes automatically. Energy transfer stays at peak efficiency across your entire production run — no operator intervention required.
Constant Amplitude Under Load — Consistent Batch Results
Amplitude holds at 100% peak-to-peak regardless of backpressure or fluid density changes. For pharmaceutical nano-emulsions and battery electrode slurries, this means your particle size distribution stays within spec batch after batch.
Linear Scale-Up from Lab to Production
Process optimization at lab scale transfers directly. Hold amplitude constant, adjust flow rate to match the same energy density (Ws/mL), and the production unit replicates your R&D results. No re-optimization required at scale.
| Feature | What It Means for Your Process |
|---|---|
| Automatic Frequency Tuning | Stable cavitation intensity across temperature and load changes |
| Constant Amplitude Control | Reproducible particle size results batch after batch |
| CIP/SIP Compatible Design | Electropolished interiors + sanitary tri-clamp fittings meet cGMP standards |
| Explosion-Proof Configuration | Full ATEX-compatible build for hazardous solvent environments |
| PLC Integration Ready | Program timed cycles, amplitude ramps, and automatic shutdowns |
| Jacketed Flow Cell | Precise temperature control during continuous operation |
| Pressure Rating to 10 bar | Supports sterile injectable and pressurized process environments |
When you pump fluid through the inline flow cell, the titanium sonotrode vibrates at 20kHz or 24kHz — faster than sound. These vibrations seed millions of microscopic bubbles in the liquid. Each bubble implodes violently, releasing localized pressure and shear forces strong enough to break particles, droplets, and agglomerates down to sub-micron or nanoscale sizes.
Why this matters for industrial scale:
Unlike rotor-stator mixers or high-pressure industrial ultrasonic homogenizers, there are no narrow orifices or valve seals. High-solid dispersions, fibrous materials, and abrasive slurries pass through without clogging or blockage — reducing downtime and maintenance costs significantly.
The jacketed flow cell circulates glycol or chilled water continuously, keeping process temperature within your target range even at full 4000W output.
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Model
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BL-10EX
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BL-20EX
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BL-30EX
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BL-50EX
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BL-100EX
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BL-150EX
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BL-200EX
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Volume(L)
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10
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20
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30
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50
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100
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150
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200
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Power(W)
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180
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180
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180
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180
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370
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750
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750
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Vacuum degree(Mpa)
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0.0968
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0.0968
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0.098
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0.098
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0.098
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0.098
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0.098
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Speed(Ram)
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0~600
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0~600
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0~600
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0~600
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0~600
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0~600
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0~600
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Stirring rod
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Stainless steel wrapped with PTFE
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Thermometer
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PT100
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Ultrasonic processor system
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Can be customize as your demand
10~3000w ultrasonic power can be adjusted
frequency : 19.5-20.5KHz Automatic tracking
titanium alloy probe /horn: Φ40 or customzie
ultrasonic process time :0 ~ 99 hours 59 minutes 59 seconds can be adjustable,:
Self-diagnostic function, program automatic error correction, over-load / over- temp..etc
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Voltage
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220V/50HZ or 380V
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Glass material
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3.3 high borosilicate glass
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Frame material
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304 stainless steel
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Optional
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Heating circulator,cooling circulator,vacuum pump,metering pump,peristaltic pump,PH meter...
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Grade 5 titanium alloy — the active processing component. Expected service life:
Visual inspection is recommended every 500 operating hours. Replacement sonotrodes are stocked for fast dispatch.
| Service | Details |
|---|---|
| Warranty | 1-year quality warranty + lifetime maintenance support |
| Spare Parts | Sonotrodes, flow cells, sealing kits — stocked for fast dispatch |
| Remote Commissioning | Step-by-step guidance + full documentation package |
| Factory Acceptance Test | On-site FAT available before shipment |
| Shipping | Sea, rail, and air freight worldwide |
Pharmaceutical & Cosmetic Nano-Emulsions
Produces stable lipid nanoparticles, liposomal delivery systems, and CBD emulsions with droplet sizes routinely below 100nm. The inline design prevents phase separation and Ostwald ripening during scale-up.
Lithium Battery Electrode Slurries
Deagglomerates carbon nanotubes, graphene, and conductive inks to single-dispersed particles without damaging CNT aspect ratio. Lowers slurry viscosity and improves electrode conductivity uniformity.
Botanical & Herbal Extraction
Cavitation mechanically disrupts plant cell walls (sonoporation), releasing polyphenols, flavonoids, and proteins into cold solvents. Extraction time drops from hours to minutes compared to thermal maceration — with no heat degradation of active compounds.
Biopharma & Fine Chemicals
Supports catalysis enhancement, controlled crystallization, and sterile injectable preparation under pressures up to 10 bar. Compatible with cGMP-compliant cleanroom integration.
Every unit ships with full CE, ISO, UL, and SGS documentation.
Pre-shipment inspection protocol includes:
Q: How does scale-up from lab to production work?
A: Scale-up is based on energy density (Ws/mL). Keep amplitude identical to your lab setting, then adjust flow rate so fluid receives the same energy per milliliter. The production unit replicates lab particle size results without re-optimization.
Q: How long does the sonotrode last?
A: Service life ranges from 3 months (highly abrasive ceramic slurries) to 3 years (organic emulsions). We recommend visual inspection every 500 operating hours. Replacement probes are available from stock with typical dispatch within 3 business days.
Q: Can it process high-viscosity pastes or thick slurries?
A: Yes — but the system requires a positive displacement pump (gear pump or peristaltic pump) to feed material into the flow cell. The ultrasonic unit generates cavitation, not suction. We can advise on pump selection based on your viscosity and flow rate targets.
Q: How does it compare to a high-pressure homogenizer?
A: No narrow orifices means no clogging risk with high-solid content dispersions, fibrous materials, or abrasive slurries. Fewer moving parts also means lower maintenance costs and less downtime versus high-pressure valve-based systems.
Q: Is temperature control required during operation?
A: Yes. Ultrasonic mechanical energy partially converts to heat. The jacketed flow cell circulates glycol or chilled water to hold your target process temperature. For continuous 24/7 operation at full power, an external chiller is recommended.
Q: What certifications does the unit carry?
A: CE, ISO, UL, and SGS — documentation included with every shipment. Explosion-proof builds carry full ATEX-compatible certification. All paperwork is formatted for regulatory audit submission.
📧 info@biolandequip.com — Send your industrial ultrasonic homogenizer process parameters (flow rate, material, target particle size), and we will respond with a custom solution within 24 hours.
2024-05-16
Pharmaceutical Company
The reactor is beautifully mirror-polished and fully complies with GMP requirements for the pharmaceutical industry. The performance is excellent! Overall, we are very satisfied! We also provided with some feedback on our process improvements, which we hope will be helpful.
2024-04-09
Laboratory
Excellent and professional service. Always reply our questions very fast. All reactors and chiller we received are good too.
2024-02-15
Research Institute
Quality is beyond our expectation actually. After we got the extraction equipment and started using it, the performance was beyond our expectation. Very easy to use and very efficient to run. Service always respond us very quickly. Was also very helpful to help us. Thanks Bioland team. Very happy to work with you.
2023-11-20
Biotech Company
We are happy about the new purchase as always. Equipment and services are both good.
2023-08-05
Instrument Lab
This is the second order with Bioland instrument and everything is good as the first dateText.
2023-05-12
Global Trading Partner
Bioland instrument team is very helpful and professional. The sales helped us select the right equipment for our application, and their logistics people handled the transportation and customs declaration for our shipment. All that saved us a lot of work.
