Xi'an Bioland's Crystallization Filter Reactor integrates reaction, crystallization, filtration, washing, and vacuum drying into a single closed vessel, eliminating yield loss and contamination risks associated with material transfer. The operating temperature range covers −80°C to 250°C, with pressure ranging from full vacuum (1 mbar) to 10 bar. Compliant with GMP/FDA material standards, certified to CE, ISO, UL, and SGS, and with over 200 units delivered across the pharmaceutical, fine chemical, and plant extraction industries.
Fully Closed "One-Pot" Process
Eliminates the centrifuge and separate dryer — from raw material reaction to dry product discharge, no lid opening or transfer is required throughout the entire process, directly reducing operator exposure risk to toxic intermediates. One piece of equipment completes the validation.
Electropolished Internal Surface (Ra ≤ 0.4µm)
The validated surface roughness value meets biofilm control requirements, supports CIP/SIP automated cleaning validation, and achieves batch-to-batch residue levels compliant with the strictest requirements for aseptic API production.
Multiple Material Options for Corrosive Conditions
Wetted parts are available in SS316L, Hastelloy C-22, Duplex 2205, or PTFE, matched progressively according to solvent corrosiveness — no need to pay material redundancy costs for a general-purpose configuration.
Explosion-Proof & Inerting Protection
Explosion-proof motor (ATEX/Class I Div 1) + ATEX sensors + nitrogen purge interlock, maintaining oxygen concentration below the Lower Explosive Limit (LEL) throughout, suitable for Class A solvents such as n-hexane and acetone.
Step 1 — Reaction & Cooling Crystallization
Materials complete the reaction within the closed vessel. Under nitrogen protection, cooling crystallization occurs, and the target solid precipitates, preventing oxidative side reactions.
Step 2 — In-Situ Filtration
The agitator moves vertically upward, and the filtrate is discharged through the bottom sintered metal mesh plate — no transfer to a centrifuge required.
Step 3 — Rake Scraping & Cake Compaction
The rake agitator rotates and presses downward, leveling and compacting the filter cake layer, eliminating cracks and ensuring uniform penetration during subsequent drying.
Step 4 — Solvent Washing (In-Situ)
The agitator re-suspends the filter cake, and wash solvent flushes away impurities before filtration again — no lid opening, no cross-contamination risk.
Step 5 — Vacuum Drying
Hot gas penetrates and dries through the uniform filter cake layer, reducing residual solvent to target levels — fully enclosed and recordable throughout.
Step 6 — Side Valve Discharge
Dried solid is discharged through the side valve; for viscous or thixotropic products, scraper blades are activated to physically detach material from the vessel wall and mesh plate.
Pharmaceutical API Production
Cooling crystallization, filtration, and solvent washing of APIs such as antibiotics and oncology drugs. The closed design meets OEL occupational exposure limit requirements for HPAPIs.
Fine Chemicals & Agrochemical Intermediates
Corrosion-resistant material configurations support direct switching from high-temperature reaction to solid-liquid separation, recovering catalysts or separating terminal particulate products.
Plant Extraction & CBD Separation
Ethanol extract undergoes freeze wax precipitation, filtration, and heated solvent recovery within the same vessel — winterization process steps reduced by over 50%.
Peptide Synthesis & Chemical Intermediate R&D
Purity control and closed operation at small-to-pilot scale. Has served peptide intermediate projects for multiple CDMO companies.
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MODEL
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BL-FR10L
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BL-FR20L
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BL-FR30L
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BL-FR50L
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BL-FR100L
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Material capacity
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10L
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20L
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30L
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50L
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100L
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Jacket capacity
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≈2L
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≈5L
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≈8L
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≈15L
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≈20L
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Receiving flask
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5L
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10L
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10L
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20L
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20L
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Reactor body and cover
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Apply vacuum grease to the connection surface between the upper part of the kettle body and the kettle cover.
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Variable-frequency governor
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Digital temperature and rotate speed
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Rotate speed
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0-300r/min
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Seal
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Self-lubricating mechanical seal
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Filter base plate
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PTFE filter sand core
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Bore diameter of sand core
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1-200μm (Optional)
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Motor power
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120W/1:3
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200W/1:3
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Power of explosion-proof motor
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180W
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370W
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370W/1:3
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Voltage
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220V/50Hz which can be customized according to customer requirements
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All equipment undergoes Factory Acceptance Testing (FAT) before dispatch, including:
Customer on-site FAT witnessing or remote video review is supported. Documentation package (including test reports and material certificates) is delivered with the equipment.
Q: What are the advantages compared to a "reactor + centrifuge + dryer" three-unit combination?
A: It eliminates two material transfers, typically improving product yield by 3%–8%; cleaning validation is reduced from three pieces of equipment to one; closed operation eliminates open exposure risk to toxic intermediates.
Q: How do you prevent filter cake cracking during the drying stage?
A: The rake agitator simultaneously rotates and presses downward, compacting and leveling the cake surface to ensure uniform hot gas penetration and eliminate channeling.
Q: What is the service life of the sintered metal mesh plate?
A: Designed service life of several years or more. Backflushing and ultrasonic cleaning are supported to restore flux without removal or replacement.
Q: Can it handle flammable solvents such as n-hexane and acetone?
A: Yes. Explosion-proof components (ATEX/Class I Div 1) + nitrogen inerting system maintain oxygen concentration below LEL throughout.
Q: How is batch-to-batch cross-contamination controlled?
A: Closed design + automated CIP/SIP programs eliminate material accumulation dead zones in piping and valves found in multi-equipment configurations.
Q: What parameters can be customized?
A: Material (SS316L/Hastelloy/PTFE/titanium), pore size (1–50µm), temperature range, pressure rating, drive type, PLC automation level, and volume — all configurable on demand, with OEM/ODM support.
Have questions about Crystallization Filter Reactor? Email us at info@biolandequip.com — we respond within 24 hours.
2024-05-16
Pharmaceutical Company
The reactor is beautifully mirror-polished and fully complies with GMP requirements for the pharmaceutical industry. The performance is excellent! Overall, we are very satisfied! We also provided with some feedback on our process improvements, which we hope will be helpful.
2024-04-09
Laboratory
Excellent and professional service. Always reply our questions very fast. All reactors and chiller we received are good too.
2024-02-15
Research Institute
Quality is beyond our expectation actually. After we got the extraction equipment and started using it, the performance was beyond our expectation. Very easy to use and very efficient to run. Service always respond us very quickly. Was also very helpful to help us. Thanks Bioland team. Very happy to work with you.
2023-11-20
Biotech Company
We are happy about the new purchase as always. Equipment and services are both good.
2023-08-05
Instrument Lab
This is the second order with Bioland instrument and everything is good as the first dateText.
2023-05-12
Global Trading Partner
Bioland instrument team is very helpful and professional. The sales helped us select the right equipment for our application, and their logistics people handled the transportation and customs declaration for our shipment. All that saved us a lot of work.
