Xi'an Bioland Instrument makes automated solid phase synthesizer systems for pharmaceutical, biotechnology, and chemical studies that are built to work in large businesses. Our synthesizer combines precise fluidics, customizable control, and strong reaction tanks to make peptide and oligonucleotide synthesis very repeatable. The system has a connection efficiency of more than 99.5% per cycle, can work in temperatures ranging from -80°C to 250°C with an accuracy of ±0.1°C, and is made of chemically strong borosilicate glass and PTFE. Our platform is compliant with CE, ISO, and GMP, and it turns complicated synthesis methods into dependable, high-throughput processes that can be used in both R&D and pilot-scale production settings.
1.The whole stainless steel column, mobile framework, 4-6 or more covers of the reaction kettle, with full set of glass parts for reflux, adding liquid, temperature measurement, and so on.
2. Use G3.3 high borosilicate glass, with good chemial and physical properties.
3. Alloy steel mechanical seal, PTFE connector, to maintain a high precision seal in the working condition.
4. With PT100 sensor probe, high precision temperature measurement, small errors, high efficiency.
5. AC reducer motor, strong torsion, no noise.
6. PTFE discharge value, moveable interface, discharging completely and quickly.
7. Our company can design special kettle boday structure according to customer requirements(such as PH meter, sand core filter etc)
8. All the reaction kettle can be made of explosion-proof device according to the customer request.(The explosion-proof device refers to the ex-proof motor + ex-proof control box + ex-proof temperature field display instrument).
9.The reactor can be a system with circulating water vacuum pump, diaphragm vacuum pump,chiller /low temperature circulator, heating and heating and cooling circulating device.
Why Choose Us?
Certified Excellence
Our equipment is certified by CE, ISO, UL, and SGS, which means it meets quality standards around the world. Every automated solid phase synthesizer meets GMP/FDA standards for making medicines.
Advanced Safety Features
To lower operating risks, we use explosion-proof systems, electric lifting mechanisms, and PLC automation as a choice. Structures with a lot of power and pressure keep your team safe during processes that use a lot of solvents.
Engineering with precision
Our internal R&D team has been making temperature control tools for more than 15 years and can get it to within ±0.1°C. German-made locks and variable-frequency shaking make sure that the product will stay stable for a long time with little upkeep.
Full Customization Capability
We offer OEM/ODM services that are suited to the needs of your business. You can choose the reactor's size, material, and built-in modules, such as those for ultrasonic crystallization, filtering, and distillation. Most stock items have a wait time of 5 to 7 days, while custom options take 30 days.
Transparent Production Tracking
During production, our specialized project experts send weekly picture and video updates. You'll look over a lot of paperwork before the shipment or set up a Factory Acceptance Test at our site.
Cost-Effective Direct Pricing
With factory-direct sales, there are no middlemen, so you save money on costs while keeping the quality high. Our guarantee lasts for one year and we offer maintenance support for life to protect your long-term business.
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MODEL |
BL-FR10L |
BL-FR20L |
BL-FR30L |
BL-FR50L |
BL-FR100L |
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Material capacity |
10L |
20L |
30L |
50L |
100L |
|
Jacket capacity |
≈2L |
≈5L |
≈8L |
≈15L |
≈20L |
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Receiving flask |
5L |
10L |
10L |
20L |
20L |
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Reactor body and cover |
Apply vacuum grease to the connection surface between the upper part of the kettle body and the kettle cover. |
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Variable-frequency governor |
Digital temperature and rotate speed |
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Rotate speed |
0-300r/min |
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Seal |
Self-lubricating mechanical seal |
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Filter base plate |
PTFE filter sand core |
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Bore diameter of sand core |
1-200μm (Optional) |
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Motor power |
120W/1:3 |
200W/1:3 |
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Power of explosion-proof motor |
180W |
370W |
370W/1:3 |
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Voltage |
220V/50Hz which can be customized according to customer requirements |
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Solid-phase synthesis is done automatically by the synthesizer, which uses repetitive chemical processes on insoluble resin supports. The process starts with adding the resin to the reaction tank. Next, chemicals like piperidine are used to deprotect the resin automatically. The method sends active amino acids or nucleotides for coupling reactions after thorough washing cycles.
Precision pumps in our tools make sure that the right amount of liquid is delivered every time, with accuracy of ±1% in gravimetry and stoichiometry. Temperature control layers keep the reaction conditions just right, and preset stirring keeps the glue from sticking together. Optional UV-Vis monitors track deprotection success in real time, which lets the system change cycle times on the fly.
The clear body of the reactor lets you see how the reaction is going. When the sequence is done, automatic cleavage methods separate the synthesized molecule from the resin. Integrated filtering gets rid of solid supports, and optional distillation units clean the end product. The whole process happens in a closed system.
Application Fields
Pharmaceutical Development
Perfect for making medicinal peptides like insulin analogues, GLP-1 agonists, and antibacterial peptides. The method allows for the production of clinical study materials that follow cGMP guidelines.
Biotechnology Research
Perfect for making neoantigen vaccines and using personalized medicine. High-throughput peptide library screening is possible with parallel synthesis.
Production of Chemicals
Helps make chemical intermediates and active pharmaceutical ingredients (APIs) that are consistent from batch to batch.
Oligonucleotide Synthesis
Antisense oligonucleotides (ASOs) and siRNA sequences can be handled by special setups that are very good at linking and controlling moisture.
Academic Research
University labs that are working on new ways to synthesize substances and studying the relationships between peptide structure and function can use micro-scale processes that are flexible.
CDMO Services
Our flexible production lines can be used for anything from method research to trial production, which is good for companies that do contract manufacturing.
Xi'an Bioland Instrument maintains comprehensive quality management systems certified to international standards:
Good production Practice (GMP) rules guide our production processes, which guarantees the standard of pharmaceutical-grade equipment. All synths go through strict Factory Acceptance Testing, which checks the accuracy of their liquid handling (within ±1% of the target), their ability to maintain a constant temperature, and their ability to withstand pressure without leaking.
To meet your legal needs, we offer full documentation packages that include Installation Qualification (IQ) and Operational Qualification (OQ) processes.
Q: What scale capabilities does your synthesizer offer?
A: Our systems range from micromolar research scales to multi-kilogram pilot production. Reactor vessels are interchangeable, maintaining consistent mixing efficiency across scale-up.
Q: How do you ensure temperature accuracy for sensitive reactions?
A: We utilize PID intelligent controllers with ±0.1°C precision and heating/cooling jackets that eliminate thermal gradients. Optional microwave heating modules accelerate kinetics while preventing racemization.
Q: Can the system handle hazardous solvent recycling?
A: Yes. Our equipment includes solvent recovery modules with smart algorithms calculating precise volumes based on resin swelling factors. Waste stream analysis validates recycling efficiency, significantly reducing environmental impact.
Q: What maintenance does the fluidic system require?
A: We recommend automated cleaning cycles with methanol or DCM after each run. Annual valve diaphragm replacement ensures continued tightness. Our preventive maintenance protocols minimize downtime.
Q: Is the control software validated for pharmaceutical use?
A: Premium models support 21 CFR Part 11 compliance with user access controls, electronic signatures, and unalterable audit trails—essential for regulatory submissions.
Q: How do you verify synthesizer performance before delivery?
A: We synthesize a challenging test sequence (typically a hydrophobic 10-mer) and analyze crude purity via HPLC and mass spectrometry. Results must exceed 85-90% purity to confirm equipment capability.
Ready to enhance your synthesis capabilities with an automated solid phase synthesizer? Contact our technical team at info@biolandequip.com for customized solutions and detailed quotations today.
2024-05-16
Pharmaceutical Company
The reactor is beautifully mirror-polished and fully complies with GMP requirements for the pharmaceutical industry. The performance is excellent! Overall, we are very satisfied! We also provided with some feedback on our process improvements, which we hope will be helpful.
2024-04-09
Laboratory
Excellent and professional service. Always reply our questions very fast. All reactors and chiller we received are good too.
2024-02-15
Research Institute
Quality is beyond our expectation actually. After we got the extraction equipment and started using it, the performance was beyond our expectation. Very easy to use and very efficient to run. Service always respond us very quickly. Was also very helpful to help us. Thanks Bioland team. Very happy to work with you.
2023-11-20
Biotech Company
We are happy about the new purchase as always. Equipment and services are both good.
2023-08-05
Instrument Lab
This is the second order with Bioland instrument and everything is good as the first dateText.
2023-05-12
Global Trading Partner
Bioland instrument team is very helpful and professional. The sales helped us select the right equipment for our application, and their logistics people handled the transportation and customs declaration for our shipment. All that saved us a lot of work.
