The CBD crystallization reactor from Xi'an Bioland Instrument is a commercial-grade heat processing tank designed for the extraction of high-purity CBD from hemp distillate. Our method provides solid CBD that is more than 99% pure by precisely controlling the temperature from -80°C to 250°C within a range of ±0.1°C. The reactor is made of pharmaceutical-grade 316L stainless steel and has an electropolished interior (Ra ≤0.4μm). It meets all GMP and FDA standards around the world. The product is designed to not explode (ATEX/Class 1 Division 1) and has PLC control and variable-frequency stirring systems with covers that were made in Germany. With more than 15 years of experience in manufacturing, we offer filter materials that can be customized, such as PTFE, titanium, and stainless steel. Our modular setups include ultrasonic crystallization, vacuum distillation, and automatic cooling ramps to ensure uniform performance from batch to batch.
The CBD crystallization reactor is commonly used device in fields like chemistry and biology, integrates the functions of reaction and separation. It consists of a reaction vessel, a filtration unit, a stirring system, a heating - cooling system, feed and discharge ports, and pipelines. During operation, reactants are first introduced into the kettle. After thorough reaction with the assistance of stirring, the filtration unit is utilized to separate the solid - liquid mixture. This equipment is applied in various fields, including the fine - chemical industry (such as the synthesis of dyes and fragrances), the pharmaceutical industry (for drug synthesis and intermediate preparation), bio - engineering (like biological fermentation), and food - additive production (such as the production of preservatives and sweeteners).
Product Features
1.The glass components are made of G3.3 borosilicate glass with good chemical and physical properties, such as: corrosion resistance and heat resistance.
2.Routinely applicable temperature range: high temperature experiment (maximum temperature is 200℃), low temperature experiment (minimum temperature is -80℃).
3.Frequency conversion speed control, gear motor, constant adjustable speed, low noise, strong torque, safe and stable.
4.PTFE paddles for stirring and mixing of low to high viscosity liquids(stirring paddle type selectable).
5.PTFE stirring paddle, suitable for stirring and mixing of low to high viscosity liquids. At the same time, you can choose different types of stirring paddles (anchor, paddle, frame and other mixing blades).
6.Other functional devices (explosion-proof device, PH monitoring, ultrasonic device, etc.) can be extended and customized according to specific needs.
Why Choose Bioland's CBD Crystallization System?Certified Quality & Global Standards
There are certificates from CE, ISO, UL, and SGS on your gear. We make sure that every reactor meets the FDA's material standards and GMP design guidelines. It gives you peace of mind to know that your production meets standards for medicinal grade from the start.
When working with explosive alkane fluids like pentane, you need to take extra safety precautions. Our fundamentally safe sensors, explosion-proof motors, and conductive PTFE gaskets get rid of the chance of sparks. You can work with confidence in dangerous places.
The PID smart system keeps the temperature accurate to within ±0.1°C over the whole working range. You have full control over nucleation dynamics whether you cool slowly at 5°C/hour to make big crystals or heat quickly to get the solvent back.
Your method is different. We can change the size of the reactor, the way the jacket is set up, the type of stirring (anchor, paddle, or fan), and where the ports are placed. Need crystallization with ultrasonic help or certain filter mesh sizes? It's built into your system by us.
Since we are factory-direct sellers, we don't have to pay markups to middlemen. You can get industrial-grade gear at prices that are 20–30% less than what it costs on the market. Your projects stay on track with our 30-day custom build time and 5- to 7-day stock available.
Our engineering team doesn't disappear after sale. You receive weekly production updates with photos and videos. We offer FAT testing at our facility and provide lifetime maintenance support beyond the one-year warranty.
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MODEL |
BL-FR10L |
BL-FR20L |
BL-FR30L |
BL-FR50L |
BL-FR100L |
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Material capacity |
10L |
20L |
30L |
50L |
100L |
|
Jacket capacity |
≈2L |
≈5L |
≈8L |
≈15L |
≈20L |
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Receiving flask |
5L |
10L |
10L |
20L |
20L |
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Reactor body and cover |
Apply vacuum grease to the connection surface between the upper part of the kettle body and the kettle cover. |
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Variable-frequency governor |
Digital temperature and rotate speed |
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Rotate speed |
0-300r/min |
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Seal |
Self-lubricating mechanical seal |
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Filter base plate |
PTFE filter sand core |
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Bore diameter of sand core |
1-200μm (Optional) |
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Motor power |
120W/1:3 |
200W/1:3 |
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Power of explosion-proof motor |
180W |
370W |
370W/1:3 |
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Voltage |
220V/50Hz which can be customized according to customer requirements |
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Our crystallization machine works by using the idea of controlled supersaturation. Simply follow these steps:
In the first step, making the solution, you dissolve the crude CBD oil in pentane or heptane, which are non-polar liquids, at high temperatures. The jacket heating system keeps the temperature evenly spread so that complete breakdown happens.
Step 2: Controlled Cooling: The jacket ventilation system starts cooling steps that have been pre-programmed. When the temperature drops, the solution moves into the metastable zone, which is where CBD bioavailability starts to drop. It keeps things uniform without messing up the nuclei that are forming because of the low-shear swirling method.
Stage 3: Nucleation and Growth: When CBD molecules reach a certain level of supersaturation, they start to make crystal lattices. Since the temperature is carefully controlled, there is no "crashing," which traps impurities. Large crystals with perfect geometry are made by controlled, slow growing.
Step 4: Harvesting: The PTFE sandcore filter removes the crystals from the mother liquor once crystallization is done. There is no product loss because of the flush-bottom release valve. The condenser port lets the recovered liquid go back into your system.
For your pharmaceutical-grade CBD to be pure, it needs to be above 99.9% of the time. Our reactor systems make it possible for generic seizure drugs and materials for clinical trials to be made over and over again. Full datalogging makes sure that 21 CFR Part 11 is followed.
To make goods without THC from full-spectrum oil, it's important to separate the cannabinoids efficiently. For legal dumping or additional processing, the CBD crystallization reactor separates pure CBD from THC in the mother liquor.
How CBD dissolves in your recipes depends on the size of the crystals. You can change the shape of the crystals in our reactors so that you can make smaller crystals for skin goods or bigger crystals for oil-based ones.
The quality of the ingredients in supplements needs to be constant. You can make CBD crystals that dissolve in water or particles of a certain size that meet your packaging needs.
In addition to CBD, the reactor can crystallize other chemical compounds as well. The exact control methods work well for pharmaceutical intermediates, specialty chemicals, and peptide synthesis.
Full quality control methods are kept up by Xi'an Bioland Instrument. The factory where we make things has ISO 9001:2015 approval for quality control. All electrical parts have CE approval to make sure they work with the European market. Pressure tanks that are recognized by UL meet the necessary safety standards. SGS's review of our production processes as a third party verifies them.
Before being shipped out, every product goes through a stringent factory test. For all of our tools, we give full material traceability paperwork, pressure test certificates, and calibration records. Our design paperwork that is GMP-compliant helps you meet your building validation needs.
Q: What purity levels can I achieve with your reactor?
A: Properly operated systems consistently produce CBD isolate exceeding 99% purity. With optimized cooling rates and multiple recrystallization cycles, you can reach 99.9%+ pharmaceutical grade.
Q: How do you ensure batch-to-batch consistency?
A: Our PLC systems store proven recipes with exact temperature profiles, stirring speeds, and timing. You simply load your parameters and the system executes identically every time.
Q: Can I see the crystallization process happening?
A: Yes. We install sight glass ports at strategic positions. You monitor nucleation points and crystal growth in real-time without opening the system.
Q: What's included in your after-sales support?
A: You receive installation guidance, operator training, one-year parts warranty, and lifetime technical consultation. We troubleshoot remotely and ship replacement parts globally.
Q: Do you support small-scale R&D work?
A: Absolutely. Our 10L and 20L benchtop models serve laboratory research perfectly. The same control systems scale directly to production volumes.
Q: How long does customization take?
A: Standard modifications require 30 business days from design approval to shipment. Complex integrations may extend to 45 days depending on specifications.
Q: What solvents are compatible with the reactor?
A: The SS316L construction handles pentane, heptane, ethanol, methanol, and most organic solvents. For highly corrosive applications, we recommend Hastelloy or glass-lined options.
Q: Can I integrate this with existing equipment?
A: Yes. We design interface connections matching your current distillation columns, chillers, and vacuum systems. Provide your specifications and we'll ensure compatibility.
Ready to optimize your CBD production with a CBD crystallization reactor? Our engineering team is standing by to discuss your specific requirements. Reach out today for technical consultation and customized solutions: info@biolandequip.com
2024-05-16
Pharmaceutical Company
The reactor is beautifully mirror-polished and fully complies with GMP requirements for the pharmaceutical industry. The performance is excellent! Overall, we are very satisfied! We also provided with some feedback on our process improvements, which we hope will be helpful.
2024-04-09
Laboratory
Excellent and professional service. Always reply our questions very fast. All reactors and chiller we received are good too.
2024-02-15
Research Institute
Quality is beyond our expectation actually. After we got the extraction equipment and started using it, the performance was beyond our expectation. Very easy to use and very efficient to run. Service always respond us very quickly. Was also very helpful to help us. Thanks Bioland team. Very happy to work with you.
2023-11-20
Biotech Company
We are happy about the new purchase as always. Equipment and services are both good.
2023-08-05
Instrument Lab
This is the second order with Bioland instrument and everything is good as the first dateText.
2023-05-12
Global Trading Partner
Bioland instrument team is very helpful and professional. The sales helped us select the right equipment for our application, and their logistics people handled the transportation and customs declaration for our shipment. All that saved us a lot of work.
