100L Crystallization Reactor

100L Crystallization Reactor - Professional Pilot-Scale Solution

Our enterprise-grade 100L Crystallization Reactor from Xi'an Bioland Instrument is designed to work with both lab research and industry production. With a working amount of 100 litres (120L total capacity), this pilot-scale vessel gives you exact control over supersaturation, nucleation, and crystal growth. It can work at temperatures ranging from -80°C to 250°C and is made of high-borosilicate glass 3.3 or electropolished SS316L (Ra < 0.4μm). It can also agitate at speeds between 0 and 600 RPM and can operate in a high vacuum (-0.098 MPa). We use our product to make sure that the Crystal Size Distribution (CSD) is regular, that polymorphs stay stable, and that GMP rules are followed for pharmaceutical APIs, cannabinoid separation, and making high-purity chemicals. It has CE, ISO, and explosion-proof standards, and its design ensures minimal dead space and repeatable temperature control, which makes it easy to scale up.

Product Description

Our crystallization machine is the most important link between chemistry in the lab and production on a large scale.

You can see every step of the hardening process. You can see the nucleation start and haze in real time through the clear glass body. This visual feedback is very helpful when coming up with new ways to do things.

Accurate temperature is important. Our PID smart control keeps the temperature accurate to within 0.1°C. Your answer stays in the Metastable Zone Width (MSZW) thanks to this strict rule. You get controlled crystal growth instead of rapid falling of rain or snow.

The jacketed style has two or three layers. Thermal fluids move around quickly, whether they are glycol for work in cold temperatures or silicone oil for work in high temperatures. For sensitive drug intermediates, you can use cooling ramps that go as slowly as 0.1°C/min.

You can change how much agitation there is. Based on how thick your slurry is, you can choose anchor, paddle, or hydrofoil impellers. The power from the variable-frequency motor stays the same across the whole speed range. Low-shear patterns keep the quality of the product high by stopping crystals from breaking.

Material suitability covers a lot of ground. Acids, bases, and most organic liquids can't break down high borosilicate glass. If you need more heat efficiency or pressure, choose SS316L construction with electropolished areas.

Dead zones are taken care of by the flush-bottom release valve. You get back almost all of your frozen product. During solvent collection processes, PTFE seals keep the pressure intact.

It's easy to integrate. Reflux condensers, dosing tubes, and in-situ Process Analytical Technology (PAT) tools can all fit through standard DN/tri-clamp holes. As your process changes, you can add more features.

Why Choose Us?

Over 15 Years of Expertise

Xi'an Bioland Instrument specializes in chemical process equipment. Our engineering team understands the complexities of scale-up and thermal management.

Certified Quality Assurance

Every reactor carries CE, ISO, UL, and SGS certifications. Our products meet GMP/FDA standards for pharmaceutical applications. Explosion-proof configurations (ATEX, Ex d IIB T4) are available for volatile solvents.

Factory Direct Pricing

You eliminate middleman markups. Our competitive pricing reduces your R&D and pilot-scale investment costs significantly.

Full Customization Capability

We tailor equipment to your exact specifications. Adjust dimensions, materials, stirring systems, and temperature ranges. Our OEM/ODM services deliver production lines matched to your workflow.

German-Imported Components

Critical seals and drive systems use premium imported parts. This ensures long-term stability and reduces maintenance downtime.

Transparent Production Tracking

A dedicated specialist monitors your order weekly. You receive photos or videos showing fabrication progress. Final acceptance includes comprehensive documentation before shipment.

Fast Turnaround

Standard units ship in 5-7 business days. Custom configurations are ready within 30 days. We support sea, rail, and air freight based on your timeline.

Comprehensive Warranty

One-year quality warranty covers all components. Lifetime maintenance support keeps your equipment operating at peak performance.

Proven Track Record

Our 100L Crystallization Reactor units operate successfully in peptide drug R&D facilities, antimicrobial peptide screening labs, and chemical intermediate production lines across Europe and Southeast Asia.

Technical Parameters

Working Principle

Controlled supersaturation management is important for the hardening process.

To begin, your solution is heated up before it goes into the generator. There is a uniform liquid phase because all the solids dissolve.

The cooling cycle then starts. Cooled thermal fluid is pumped around the jacketed device. The temperature drops at a set rate, usually between 0.1°C and 1°C per minute.

Solubility goes down as temperature goes down. It gets too wet for your solution. This is the very time when factors decide the quality of the crystal.

Nucleation starts. Tiny crystal seeds can form on their own or around seed crystals that were added on purpose. The stirrer keeps the conditions even inside the tank.

Crystals are still growing. Molecules from the supersaturated solution stick to the surfaces of crystals that are already there. The PID controller keeps the answer in the MSZW, which is the small area where growth is stronger than new nucleation.

Crystals stay in the air thanks to the low-shear turbine. Gentle movement keeps things from setting and keeps them from breaking mechanically. This keeps the shape and size spread of the crystals.

Adding an antisolvent is optional, but it can increase output. A falling tube slowly adds a poor miscible solvent. This makes it even less soluble and speeds up the hardening process.

Vacuum cooling is an additional method. The boiling point drops when the pressure drops. The solvent evaporates, cooling the solution and concentrating it at the same time.

The sludge finally gets to where it's supposed to be. You can use PAT probes or look through the glass wall to see when the job is done. The flush-bottom valve then lets the product out with very little loss.

Application Fields

Pharmaceutical API Production

At the small stage, recrystallize the active pharmaceutical ingredients. The GMP-compliant design of the reactor allows for clinical study group production. Accurate temperature control is needed for polymorph creation to go as planned.

Peptide Drug Development

Make peptide APIs that must be very stable at high temperatures. The gentle stirring and precise freezing in our system keep things from breaking down. Performance has been proven by a number of peptide screening projects.

Cannabinoid Isolation

Pure CBD concentrate from hemp products should be crystallized. Cryogenic ethanol liquids as cold as -80°C can be used in the reactor. Strong closing keeps the solvent from evaporating during long dwell times.

Chemical Intermediates

Make unique chemicals that are very valuable. The flexible platform can work with a wide range of chemicals, from acid chlorides to organometallics.

Electronic Chemical Starters

Make materials that are very, very pure for making semiconductors. Metal ions can't get into parts that are sealed with PTFE below PPB levels.

Fine Chemical Synthesis

Grow the ways that agrochemicals, dyes, and colours are made in the lab. Crystallization that works well makes products more consistent and cuts down on waste.

Biopharmaceutical Buffers

Get buffer salts and high-purity solid excipients ready. Batch-to-batch reproducibility is ensured by the obvious process tracking.

New Material Development

Synthesize novel crystalline compounds for energy storage, catalysis, or optoelectronics. Modular design accommodates experimental protocols.

Quality Certification

Xi'an Bioland Instrument keeps high standards for quality:

• ISO 9001: Quality management system certification makes sure that the methods used in production are always the same.
• CE marking means that an electrical or mechanical product meets European safety standards.
• GMP Compliance: The design, the materials used, and the production all meet the standards set by Good Manufacturing Practice for medicinal uses.

Regular audits by outside parties are done at our production site. Before being sent out, every reactor is tested in the plant. There are material certificates, electrical diagrams, and working instructions in documentation packages.

You can choose to have Factory Acceptance Testing (FAT). At our Xi'an facility, you or someone from your company can look at the finished unit. Before sending, we show you how everything works and make sure it meets the performance standards.

FAQ

Q: How do I choose between glass and stainless steel construction?

A: Select glass when visual monitoring of crystallization is essential, or for highly acidic media. Choose stainless steel for better heat transfer efficiency, higher mechanical strength, or when working above 200°C.

Q: Can this reactor handle explosive solvents like hexane or ethanol?

A: Yes. Specify our explosion-proof configuration with Ex-rated motor, anti-static components, and intrinsically safe sensors. Proper grounding prevents static discharge ignition.

Q: What agitation type prevents crystal breakage?

A: Use low-shear hydrofoil or pitched-blade impellers at low RPM. Avoid high-shear dispersers. For viscous slurries, an anchor agitator with PTFE scrapers provides gentle circulation.

Q: How does the system control the Metastable Zone Width?

A: The PID temperature controller enables very slow, linear cooling ramps or programmed oscillating profiles. This keeps the solution in the optimal zone where crystal growth dominates over nucleation.

Q: What determines cooling rate efficiency?

A: Heat transfer depends on surface area to volume ratio, wall thermal conductivity (steel transfers faster than glass), and the temperature difference between jacket fluid and process fluid.

Q: Is customization available for special processes?

A: Absolutely. We customize dimensions, materials, stirring systems, temperature ranges, and port configurations. Our engineering team can integrate ultrasonic crystallization modules, distillation heads, or automated dosing systems.

Q: How long does delivery take?

A: Standard product units ship in 5-7 days. Custom configurations require approximately 30 business days from order confirmation to completion.

Q: What warranty coverage do you provide?

A: One-year warranty covers all components. Lifetime technical support and maintenance services are included. We maintain spare parts inventory for quick replacements.

Contact Us

Ready to optimize your crystallization process 100L Crystallization Reactor? Contact Xi'an Bioland Instrument today at info@biolandequip.com for technical specifications and quotations.