ultrasonic cell disrupter

Ultrasonic Cell Disrupter – High-Performance Solution for Cell Lysis & Homogenization 

Labs and factories all over the world can use our ultrasonic cell disrupter to get enterprise-level efficiency. This probe sonicator turns electrical energy into high-frequency mechanical movements at 20 kHz. This creates acoustic cavitation, which breaks down cell walls and extracts contents inside cells. It can handle sample amounts from microliters to industrial scale and has power levels that can be changed from 250W to 4000W. The probe setups can also be changed. The system has a PLC touchscreen for control, timing that can be programmed for repeated routines, and modes for pulsed and continuous operation. This unit is made with probes made of a corrosion-resistant titanium metal and has automatic frequency tracking, overload protection, and temperature monitoring (RT-90°C) to make sure the best results while keeping sensitive proteins safe. It is GMP and FDA compliant and has CE, ISO, UL, and SGS certifications.

Why Choose Xi'an Bioland Instrument?

You deserve a partner who understands your extraction challenges. With over 15 years specializing in process equipment manufacturing, we bring proven expertise to every project.

Your benefits include:

• Certified Quality: Approvals from CE, ISO, UL, and SGS make sure that the product is safe and reliable.

  

• Expert Engineering Team: Our in-house R&D engineers offer expert advice and make solutions just for you.
• Flexible Customization: OEM/ODM services can change the volume, probe size, and strength of equipment to fit your exact needs.
• Quick Shipping: Units that aren't customized ship in 5–7 days; customized systems are ready in 30 business days.
• Full Assistance: One-year warranty and maintenance for life, with weekly pictures and movies used to track growth.
• GMP/FDA Compliance: All of the goods meet the standards for making pharmaceuticals.
• Global Logistics: Fast ways for freight to get to you by sea, road, and air

We monitor every production stage closely. You'll receive detailed inspection materials before shipment, or schedule a Factory Acceptance Test at our Xi'an facility.

Technical Parameters

Working Principle

How does acoustic cavitation break cells so effectively? The ultrasonic cell disrupter transforms electrical signals into mechanical vibrations through a piezoelectric transducer.

Here's what happens inside your sample:

• Producing Vibrations: The metal probe moves through high-frequency waves (20,000 cycles per second).
• The probe tip makes waves of high and low pressure in the liquid that move back and forth. This is called cavitation formation.
• When tiny pressure bubbles form and burst within microseconds, this is called bubble implosion.
• It releases shear force and creates heat and pressures above 1,000 atmospheres in some areas where the collapse happens.
• Tough forces tear cell walls apart, letting proteins, DNA, and organelles escape.

  

   

Unlike mechanical blenders, this process achieves sub-micron particle sizes and maintains high extraction yields from tough matrices like yeast, fungi, and plant tissues.

Process Flow

Standard Operation Sequence:

• Preparing the Sample: Put your biological sample in the right container (make sure there is enough space for the probe to be submerged).
• Probe Selection: Based on the sample amount and viscosity, pick the right probe width.
• Setting parameters: Use the touchscreen to set the power amount, pulse length, and total processing time.
• Controlling the temperature: Put the vessel in a bath of ice water or connect the jacketed vessel to a fridge.

  

   

• Sonication: Put the probe 1 to 2 cm below the top of the liquid and start the automatic loop.
• Watching: The system shows the power flow, temperature, and time that has passed in real time.
• Intervals for Cooling: Pulse mode turns on and off to keep the temperature from dropping.
• When the timer runs out, the machine will automatically turn off, and a processing sample will be collected.

Pro Tip: Always use pulse mode (e.g., 5 seconds on / 3 seconds off) for protein extraction to preserve enzymatic activity.

Application Fields

This versatile instrument serves researchers and manufacturers across multiple industries:

Biotechnology & Life Sciences

• DNA/RNA extraction from bacterial, mammalian, and plant cells
• Chromatin shearing for ChIP-seq and NGS library preparation
• Protein isolation from E. coli expression systems
• Subcellular organelle separation

Pharmaceutical Development

• Recombinant enzyme recovery with maintained bioactivity
• Vaccine antigen release from viral particles
• Liposome and nanoparticle drug carrier preparation

  

   

Nanotechnology

• Carbon nanotube and graphene dispersion in solvents
• Nano-emulsion creation for cosmetics and drug delivery
• Quantum dot homogenization

Materials Science

• Polymer degradation studies
• Catalyst particle size reduction
• Composite material mixing

Food & Beverage

• Plant extract preparation (polyphenols, flavonoids)
• Microbial cell disruption for fermentation analysis
• Emulsification of food ingredients

Quality Certification

Xi'an Bioland Instrument maintains strict quality standards throughout manufacturing. Our production facility holds:

• ISO 9001 certification for quality management systems
• CE marking for European safety compliance
• UL approval for North American electrical safety
• SGS third-party inspection verification

Before it is shipped, every unit goes through a lot of tests, such as amplitude stability checks, sensor efficiency checks, and safety function checks. We promise that pharmaceutical uses will follow GMP and FDA rules.

FAQ

Q: How do I prevent sample overheating during processing?

A: Always use pulse mode with appropriate on/off intervals. Keep your sample in an ice-water bath throughout the process. For critical temperature-sensitive work, request our low-temperature configuration option.

Q: What sample volume can this equipment handle?

A: We offer solutions from 0.5 mL (microprobe tips) to continuous flow systems processing liters per hour. Tell us your volume requirements, and we'll recommend the optimal configuration.

Q: When should I replace the probe?

A: Replace when you notice surface pitting, excessive noise changes, or frequency tuning failures. Typical probe lifespan depends on usage intensity. We provide replacement probes and can restore performance through professional polishing services.

Q: Can I process hazardous or flammable materials?

A: Yes, with proper safety protocols. Request our ATEX-certified explosion-proof model for volatile solvent applications. Always operate in appropriate fume hoods with adequate ventilation.

Q: How loud is the operation?

A: The cavitation process generates sound levels above 100 dB. We strongly recommend using our optional soundproof enclosure to meet laboratory safety standards and protect operator hearing.

Q: Do you provide training and technical support?

A: Absolutely. We supply comprehensive operation manuals, video tutorials, and remote technical assistance. On-site installation and training services are available for large-scale custom systems.

Contact Us

Ready to enhance your research capabilities with ultrasonic cell disrupter? Reach out to our technical team at info@biolandequip.com for quotations, customization details, or application consultations today.