Xi'an Bioland Instrument Co., Ltd. has focused on the R&D and manufacturing of jacketed agitated reactors for over 15 years, serving the pharmaceutical, biotechnology, and fine chemical industries. Our reactors support a wide operating temperature range from −80°C to +250°C, with pressure ratings covering full vacuum to 100 bar. Vessel materials include SS316L, Hastelloy C-22, and GG17 borosilicate glass. Certified to both CE and ISO, they offer customizable PLC automation control and OEM/ODM solutions. We have provided stable, reliable process solutions to more than 200 customers worldwide.
1. Precise Thermal Management
The jacket uniformly circulates heat transfer medium, eliminating hot spots and controlling temperature fluctuation within ±0.5°C. For strongly exothermic reactions (e.g., nitration, hydrogenation), an optional rapid cooling valve assembly provides a response time of <30 seconds, effectively preventing thermal runaway.
2. Three Jacket Designs — Matched to Your Process
| Jacket Type | Best For | Max Pressure |
|---|---|---|
| Half-Pipe Coil | High-pressure steam, large vessels >5,000 L | 3.0 MPa |
| Dimple | Cost-effective cooling, small-to-mid batches | 1.0 MPa |
| Conventional | General heating/cooling duty | 0.6 MPa |
3. Application-Specific Agitation
4. Zero-Leakage Sealing for Hazardous Media
Double mechanical seal (API Plan 53A, barrier fluid pressure 0.2 MPa above process pressure) or magnetic drive coupling, suitable for toxic, flammable, and highly corrosive materials, with leakage rates meeting EPA/VOC emission standards.
5. Pharma-Grade Surface Finish
Internal wall electropolished to Ra ≤ 0.4 µm, meeting FDA 21 CFR Part 211 cGMP cleanliness requirements, supporting CIP/SIP clean-in-place and sterilization, preventing biofilm formation.
For high-viscosity systems, the PTFE wall scraper attached to the anchor agitator continuously cleans the inner wall, preventing product coking and maintaining a stable heat transfer coefficient (typical value: U = 300–800 W/m²·K, depending on material viscosity and flow rate).
Material Selection Guide
| Material | Chemical Compatibility | Recommended Application |
|---|---|---|
| SS316L (Mo 2.1–2.8%) | Weak acids, bases, organic solvents | General pharmaceutical & chemical |
| Hastelloy C-22 | Hydrochloric acid, sulfuric acid, oxidizing strong acids, chloride-containing media | Fine chemicals, pesticide intermediates |
| Glass-Lined Steel | Strongly corrosive organics | Dyes, resins |
| GG17 Borosilicate Glass | All chemical categories, visual observation | Laboratory & pilot scale |
Weld Quality Assurance
| Comparison Dimension | Bioland | Typical Trading Company |
|---|---|---|
| Manufacturing Experience | 15 years, own factory | No in-house production |
| Design Capability | CFD-assisted selection, direct engineer communication | Relies on fixed product catalog |
| Customization Capability | Nozzle layout / special alloys / skid integration | Limited or non-customizable |
| Delivery Transparency | Weekly production progress photo/video updates | Usually no intermediate feedback |
| After-Sales Support | 1-year warranty + lifetime maintenance service agreement | Usually no after-sales |
Our commitments:
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type
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volume
(L)
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Motor power
(W)
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Speed
(r/min)
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Stirring torque(1300r/min)
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Inside/outside tube diameter
(mm)
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Reactor vessel cover relevant opening size
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center
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left
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right
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later
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before
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BL-150
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150
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370
|
10-680
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28000g.cm
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600*550
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50#
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40#
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34#
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34#
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29#
|
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BL-100
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100
|
250
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22000g.cm
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460*500
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50#
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40#
|
34#
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34#
|
29#
|
|
BL-80
|
80
|
250
|
|
22000g.cm
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460*500
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50#
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40#
|
34#
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34#
|
29#
|
|
BL-50
|
50
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180
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15000g.cm
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360*405
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50#
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40#
|
34#
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34#
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29#
|
|
BL-30
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30
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180
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15000g.cm
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315*360
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50#
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40#
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34#
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34#
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29#
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BL-20
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20
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120
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12000g.cm
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315*360
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50#
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40#
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34#
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34#
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29#
|
|
BL-10
|
10
|
120
|
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12000.g.cm
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245*260
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50#
|
40#
|
34#
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34#
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29#
|
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BL-5
|
5
|
90
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9000.g.cm
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200*230
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50#
|
29#
|
24#
|
24#
|
19#
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Pharmaceutical API Synthesis
Precise cooling curve control through the jacket (typical rate: 0.5–2°C/min) regulates crystal habit and particle size distribution (D90 target value can be set). Electropolished interior meets CIP/SIP requirements, avoiding batch-to-batch cross-contamination.
Customer case: A domestic API manufacturer adopted our 500 L SS316L jacketed agitated reactor in a sulfate compound crystallization process, reducing product particle size D90 variation from ±15 µm to ±4 µm, with batch qualification rate increased to 99.2%.
Polymer Resin Production
Helical ribbon agitator combined with internal wall scraper maintains stable inner wall heat transfer coefficient throughout the entire polymerization process as viscosity climbs from an initial 200 cP to 50,000+ cP, preventing yellowing and degradation caused by localized overheating.
Fine Chemical Hydrogenation
Gas-induction impeller recycles headspace hydrogen, achieving gas-liquid mass transfer coefficient (kLa) of 0.08–0.15 s⁻¹ at 5.0 MPa operating pressure. The jacket simultaneously removes reaction heat (typical value: −80 kJ/mol), maintaining isothermal operation.
Biotech & Fermentation
Low-shear anchor or frame agitators (tip speed <1.5 m/s) protect cell viability. Jacket temperature control accuracy ±0.5°C, supporting 72–120 hour long-cycle batch fermentation. DO control and pH interlocking can be integrated into the PLC system.
Standard delivery documentation package:
Weld inspection reports | Hydrostatic test records | Surface roughness (Ra) measurement reports | Material certificates (Mill Certificate) | CE Declaration of Conformity | Operation & maintenance manual
Factory Acceptance Test (FAT): Customers may arrange on-site acceptance at our Xi'an factory before shipment, or a complete video acceptance service is available.
Three steps to start your project:
Fill in the process parameter table (temperature, pressure, material, volume) → send to info@biolandequip.com
Engineer responds within 48 hours with preliminary selection recommendations and quotation
Confirm the solution and place your order; a dedicated follow-up specialist tracks the entire process through to delivery
📧 Get selection advice or a quotation: info@biolandequip.com
Tell us your process conditions, and we will recommend the most suitable jacket and agitator combination for you.
Q: What are the main design differences between laboratory pilot reactors and industrial production reactors?
Pilot reactors (5–50 L) typically use GG17 glass material for visual observation, with a wider agitation speed range (10–1500 rpm). Industrial reactors prioritize the scale-up effect of heat transfer area-to-volume ratio (A/V value) — this is key to successful process scale-up, and we use CFD models to predict it in advance during the design stage.
Q: Which jacket type should be selected for high-pressure steam heating?
The Half-Pipe Coil Jacket is recommended, suitable for large reactors >5,000 L and steam pressures >1.0 MPa. Its structural rigidity is significantly superior to dimple jackets.
Q: How do you address the decline in heat transfer efficiency for high-viscosity materials?
Anchor agitators equipped with PTFE or metal wall scrapers continuously remove the inner wall boundary layer, maintaining the heat transfer coefficient of viscous systems above 85% of the design value.
Q: Which sealing solution should be selected for toxic or highly corrosive materials?
Both double mechanical seals (API Plan 53A) and magnetic drive couplings achieve zero leakage. Magnetic drive has no dynamic sealing elements, offering longer maintenance intervals and suitability for continuous production; Plan 53A is suitable for working conditions requiring rapid disassembly and maintenance.
Q: How is mixing time predicted during the design stage?
Mixing time depends on the agitator discharge coefficient (Nq), vessel-to-impeller diameter ratio (D/T), and fluid viscosity. We use ANSYS Fluent for CFD simulation and can provide a mixing time prediction report during the design stage for process engineer confirmation.
Q: What technical documents are provided with each reactor?
Weld RT/PT inspection reports, hydrostatic test records, surface roughness (Ra) inspection reports, Positive Material Identification (PMI) certificates, CE Declaration of Conformity, material certificates (Heat Certificate), and a complete operation and maintenance manual.
Need technical consultation or a custom quotation for a jacketed agitated reactor? Feel free to contact us anytime: 📧 info@biolandequip.com — we will respond within 48 hours.
2024-05-16
Pharmaceutical Company
The reactor is beautifully mirror-polished and fully complies with GMP requirements for the pharmaceutical industry. The performance is excellent! Overall, we are very satisfied! We also provided with some feedback on our process improvements, which we hope will be helpful.
2024-04-09
Laboratory
Excellent and professional service. Always reply our questions very fast. All reactors and chiller we received are good too.
2024-02-15
Research Institute
Quality is beyond our expectation actually. After we got the extraction equipment and started using it, the performance was beyond our expectation. Very easy to use and very efficient to run. Service always respond us very quickly. Was also very helpful to help us. Thanks Bioland team. Very happy to work with you.
2023-11-20
Biotech Company
We are happy about the new purchase as always. Equipment and services are both good.
2023-08-05
Instrument Lab
This is the second order with Bioland instrument and everything is good as the first dateText.
2023-05-12
Global Trading Partner
Bioland instrument team is very helpful and professional. The sales helped us select the right equipment for our application, and their logistics people handled the transportation and customs declaration for our shipment. All that saved us a lot of work.
