If you compare Xi'an Bioland Instrument's enterprise-grade ultrasound assisted extraction of quercetin device to other ways, it works 50–500% better. Our high-tech equipment works at safe low temperatures (40–60°C), so extraction sessions only take 24–40 minutes, which is more than two thirds as long as they used to be. The system has full PLC control, an explosion-proof setup that can be chosen, and the ability to work with UAE, OSE, and hot reflux technologies. With available 316 stainless steel touch parts, our equipment meets GMP standards and is certified to CE, ISO, UL, SGS, ATEX, and IEC standards. We offer turnkey solutions backed by professional research and development (R&D) and full lifetime support. These solutions have been used successfully in the stevia, propolis, curcumin, and mushroom extraction lines.
Proven Engineering Excellence
We have been experts in extraction technology for more than 15 years, so we can help you make quercetin. Our research and development team knows how hard it can be to get flavonoids out of plants.
Unmatched Extraction Performance
You will get much higher amounts while keeping the beneficial quality of your quercetin. Our numbers show that traditional ways aren't nearly as effective as ours.
Complete Customization Flexibility
The things you need to make are special. We can make custom setups with features like two ultrasonic systems, solvent recovery units, CIP cleaning, and automatic release mechanisms. OEM and ODM services make sure that your exact needs are met.
Full Regulatory Compliance
Every system meets the output standards set by GMP and FDA. You don't have to worry about compliance when you use our tools to make pharmaceutical APIs, functional foods, or cosmetics.
True Turnkey Partnership
We sell more than just tools. You get full planning, installation, and commissioning of the workshop, as well as expert training and weekly progress tracking with photo and video records. Our goal is for you to succeed.
Quality Assurance You Can Trust
One-year guarantee with free servicing for life. Our professional expert team is always ready to help, so your production never has to go without for long periods of time.
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Technology parameter |
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Model |
BL-TN-C50L |
BL-TN -C100L |
BL-TN -C200L |
BL-TN -C300L |
BL-TN -C500L |
|
Volume (L) |
50 |
100 |
200 |
300 |
500 |
|
Evaporation capacity (kg/h) |
20 |
50 |
70 |
100 |
200 |
|
Motor power(KW) |
2.7 |
2.7 |
2.7 |
3.5 |
3.5 |
|
Steam consumption(kg/h) |
25 |
60 |
90 |
120 |
250 |
|
System vacuum (MPa) |
-0.085 |
-0.085 |
-0.085 |
-0.085 |
-0.085 |
|
Pressure of jacket(MPa) |
0.09~0.3 |
0.09~0.3 |
0.09~0.3 |
0.09~0.3 |
0.09~0.3 |
|
Compressed air (MPa) |
0.5~0.6 |
0.5~0.6 |
0.5~0.6 |
0.5~0.6 |
0.5~0.6 |
|
Evaporation temperature(°C) |
60~100 |
60~100 |
60~100 |
60~100 |
60~100 |
Through precise sonotrodes, the machine makes sound waves with a high frequency (20–40 kHz). The waves make sonic cavitation in the liquid used for extraction.
Cavitation Mechanism
Near the surfaces of plant cells, tiny pressure bubbles form, grow, and then rapidly pop. Each detonation releases a huge amount of energy in a small area.
Cell Wall Disruption
The strong compression forces and micro-jets break down tough cell walls mechanically. This kind of physical damage is much worse than what silent spread can do.
Rapid Mass Transfer
When cell walls are broken, quercetin inside the cells moves quickly into the solvent around it. The increased diffusion coefficient speeds up the extraction process by a huge amount.
Temperature Control
During the whole process, jacketed cooling devices keep temperatures below 50°C. This keeps the heat-sensitive quercetin molecule from breaking down, so its antioxidant power is kept.
Continuous or Batch Mode
Ultrasonic baths are usually used for batch preparation in the lab. For metric-ton output, industrial devices use continuous-flow reactors with probe sonotrodes.
1. Raw Material Preparation
Your botanical material (Sophora japonica buds, onion skins, apple pomace) is cleaned, dried, and ground to optimal particle size (typically 20-60 mesh).
2. Loading and Solvent Addition
Material is loaded into the extraction vessel. Solvent (typically 60-70% ethanol-water mixture) is added at predetermined solid-to-liquid ratios.
3. Ultrasonic Extraction
The system initiates ultrasonic treatment. Pulsed modes prevent excessive heat buildup while maintaining cavitation intensity. Extraction completes in 24-40 minutes.
4. Separation and Filtration
Because cavitation creates fine particles (<5 microns), we recommend centrifugation or multi-stage membrane filtration rather than standard mesh filters.
5. Concentration
The clarified extract undergoes low-temperature vacuum concentration to increase quercetin concentration while minimizing thermal exposure.
6. Solvent Recovery (Optional)
Our integrated recovery system reclaims up to 85% of solvents, significantly reducing operating costs and supporting green chemistry principles.
7. Purification and Crystallization
Further purification through recrystallization or chromatography achieves pharmaceutical-grade purity (>95% by HPLC).
8. Drying and Packaging
Final product undergoes spray drying or freeze drying, then packaging under controlled conditions.
Pharmaceutical API Manufacturing
Isolation of bioactive quercetin on a large scale from Sophora japonica buds is used as an active ingredient in medicines. Your method for ultrasound assisted extraction of quercetin allows for high-throughput, ongoing processing of drugs that reduce inflammation and alter the immune system. All parts of the design are made to comply with GMP.
Cosmetic and Dermal Formulations
Using fluids that are safe for the skin, like propylene glycol or glycerin, to directly extract quercetin while using ultrasound. Quercetin is an important ingredient in anti-aging serums because it protects against UV rays and fights free radicals. Oxidation can't happen in the low-temperature method, which keeps the product stable in complex emulsion settings.
Functional Food Additives
Food trash like red onion peels and apple cores can be turned into useful natural preservatives that are high in antioxidants. Your method effectively removes bound phenolics, creating natural ingredients that stop lipid oxidation in prepared foods and edible oils, taking the place of artificial preservatives such as BHT and BHA.
Nutraceutical Supplements
Natural antioxidant products are becoming more popular, and high-purity quercetin ingredients meet that demand. The health benefits are better because the absorption and radical scavenging power are kept.
Veterinary and Animal Health
Because it reduces inflammation, quercetin is useful for making goods that help animals. Your extraction method consistently makes safe ingredients that can be used in pet supplements and on animals.
International Safety Standards
Our equipment holds CE, ISO, UL, SGS, ATEX, and IEC certifications. These aren't just badges—they represent rigorous third-party verification of safety and performance.
GMP Compliance
Every aspect of design, material selection, and operational protocols meets Good Manufacturing Practice standards. You can confidently use our equipment for regulated pharmaceutical production.
Quality Control Support
While we manufacture extraction equipment, we understand your downstream requirements. Your extracts can be analyzed via HPLC-DAD for assay determination, GC-HS for residual solvents (ICH Q3C compliance), and ICP-MS for heavy metals screening.
Material Traceability
All stainless steel components come with mill certificates. Welding procedures follow ASME standards. You receive complete documentation for regulatory audits.
Q1: How does the product compare to Soxhlet extraction regarding yield?
UAE typically increases your quercetin yield by 15-30% compared to Soxhlet extraction while reducing process time by up to 90%. The mechanical disruption of cell walls achieves what passive diffusion cannot.
Q2: Does the ultrasound process degrade the quercetin molecule?
Not when properly controlled. Our systems use pulsed modes and jacketed cooling to maintain temperatures below 50°C, ensuring your quercetin's chemical stability remains intact.
Q3: Is this extraction method scalable for industrial production?
Absolutely. While laboratory setups use ultrasonic baths (batch mode), industrial applications utilize continuous-flow ultrasonic reactors with probe sonotrodes. You can linearly scale to process metric tons of biomass.
Q4: What is the best solvent system for this extraction method?
A 60-70% ethanol-water mixture typically delivers optimal results due to polarity matching. It also meets green chemistry standards better than methanol or acetone.
Q5: Why is filtration difficult after ultrasound extraction?
Cavitation shatters cell structures into very fine particles (<5 microns). Standard mesh filters may clog. We recommend centrifugation or multi-stage membrane filtration for best results.
Q6: What's your typical delivery timeline?
Customized equipment requires approximately 30 business days. Standard configurations ship within 5-7 business days.
Q7: Do you provide installation support?
Yes. We offer complete installation, commissioning, and on-site training. Your team will be fully operational before we depart.
Ready to transform your quercetin production efficiency with ultrasound assisted extraction of quercetin? Reach out to our technical team at info@biolandequip.com for customized solutions and quotations today.
2024-05-16
Pharmaceutical Company
The reactor is beautifully mirror-polished and fully complies with GMP requirements for the pharmaceutical industry. The performance is excellent! Overall, we are very satisfied! We also provided with some feedback on our process improvements, which we hope will be helpful.
2024-04-09
Laboratory
Excellent and professional service. Always reply our questions very fast. All reactors and chiller we received are good too.
2024-02-15
Research Institute
Quality is beyond our expectation actually. After we got the extraction equipment and started using it, the performance was beyond our expectation. Very easy to use and very efficient to run. Service always respond us very quickly. Was also very helpful to help us. Thanks Bioland team. Very happy to work with you.
2023-11-20
Biotech Company
We are happy about the new purchase as always. Equipment and services are both good.
2023-08-05
Instrument Lab
This is the second order with Bioland instrument and everything is good as the first dateText.
2023-05-12
Global Trading Partner
Bioland instrument team is very helpful and professional. The sales helped us select the right equipment for our application, and their logistics people handled the transportation and customs declaration for our shipment. All that saved us a lot of work.
