Xi'an Bioland Instrument Co., Ltd. specializes in industrial ultrasound assisted extraction machines for pharmaceutical, botanical, and food processing. Our devices work in the 20-28 kHz range with an adjustable amplitude of 20% to 100% and provide up to 500% better extraction yield than traditional Soxhlet or reflux. Low temperature processing (40-60oC) protects heat sensitive APIs, polyphenols and volatile aroma chemicals. Each unit is CE, ISO, ATEX and GMP compliant. OEM/ODM is available. Normal units ship in 5-7 days; bespoke configurations delivery in 30 business days.
If your current extraction process relies on Soxhlet, reflux, or maceration, you're likely facing three persistent problems: long batch cycles, high solvent consumption, and thermal degradation of active compounds.
Ultrasound assisted extraction solves all three at once:
The result: higher output per batch, lower operating cost, and a cleaner extract profile.
Up to 500% Higher Extraction Efficiency
Acoustic cavitation greatly speeds transport of solute from the plant matrix to the solvent. For most botanical feedstocks – including stevia leaf, propolis and cannabis flower – this means a significantly higher yield per kilogram of raw material treated.
Low-Temperature Processing (40–60°C)
Heat sensitive chemicals, such as cannabinoids, curcumin and volatile essential oils, are structurally preserved during the extraction cycle. This is an advantage over Soxhlet and reflux procedures where the operating temperature is at or above solvent boiling temperatures.
Dual-Ultrasonic Scalable Setup
Optional dual-transducer and dual-condenser versions boost throughput in the same equipment footprint. No facility expansion required.
Explosion-Proof System for Flammable Solvents
The fully ATEX/IECEx certified setup uses explosion-rated generators and inert-gas purged enclosures, ensuring the system is safe for ethanol, hexane and other Class I solvents.
Integrated CIP Cleaning & Solvent Recovery
Optional organic solvent recovery condenser and Clean-in-Place (CIP) system minimise solvent waste and inter-batch cleaning times, important for high-throughput GMP production environments.
Full Traceability PLC Automation
Operation is PLC-controlled, allowing configurable extraction processes, real-time parameter tracking and audit-trail documentation – satisfying 21 CFR Part 11 and GMP batch record requirements.
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Technology parameter
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Model
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BL-TN-C50L
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BL-TN -C100L
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BL-TN -C200L
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BL-TN -C300L
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BL-TN -C500L
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Volume (L)
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50
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100
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200
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300
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500
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Evaporation capacity (kg/h)
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20
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50
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70
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100
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200
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Motor power(KW)
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2.7
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2.7
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2.7
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3.5
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3.5
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Steam consumption(kg/h)
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25
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60
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90
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120
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250
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System vacuum (MPa)
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-0.085
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-0.085
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-0.085
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-0.085
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-0.085
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Pressure of jacket(MPa)
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0.09~0.3
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0.09~0.3
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0.09~0.3
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0.09~0.3
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0.09~0.3
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Compressed air (MPa)
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0.5~0.6
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0.5~0.6
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0.5~0.6
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0.5~0.6
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0.5~0.6
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Evaporation temperature(°C)
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60~100
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60~100
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60~100
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60~100
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60~100
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Transducer transforms electrical energy to mechanical vibration in 20 to 28 kHz range. This vibration travels through the liquid medium and creates millions of tiny cavitation bubbles every second.
When these bubbles collapse they release enormous localised energy – shear forces in excess of 1000 m/s micro-jets, temperatures in excess of 5000 K at the point of collapse and pressures up to 1000 bar in the immediate micro-environment.
These forces literally break down the walls of normal cells in plants, releasing intracellular chemicals – cannabinoids, alkaloids, polyphenols, essential oils – straight into the surrounding solvent. The bulk liquid temperature is maintained around 40-60°C, so the extracted chemicals are not subjected to harmful heat.
Jacketed flow cells with external chillers continually remove process heat and provide temperature homogeneity during the whole extraction cycle.
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Component
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Material
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Standard
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Sonotrode (Horn)
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Ti-6Al-4V Grade 5 Titanium
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ASTM B265
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Contact Surfaces
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316L Stainless Steel
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ASME BPE
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Internal Finish
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Ra < 0.8 µm electropolished
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GMP / FDA
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Alternative Probe
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Zirconia ceramic (for trace-metal-sensitive APIs)
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—
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Flow Cell Pressure Rating
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5–10 bar hydrostatic tested
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—
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All wetted components are sourced from certified suppliers and documented in material traceability records provided at shipment.
Extraction from Pharmaceutical and Botanical
Production-scale extraction of stevia glycosides, propolis flavonoids, capsaicin, curcumin, and mushroom beta-glucans using an ultrasound assisted extraction machine. The device can accommodate high-viscosity slurries and fibrous plant matrices, maximising API release to ethanol or aqueous-ethanol systems.
Cannabis & Hemp Processing
Full spectrum cannabis & terpene extraction without thermal degradation. The acoustic cavitation increases the rupture of the cells in the trichome-rich material, resulting in better yields per gram of biomass than the cold maceration.
Food Technology & Functional Ingredients
Extraction of polyphenols from fruit peels and grape pomace. Protein isolation from soy and pea. Recovery of antioxidants from processing by-products. The acoustic process can change protein solubility and emulsification behaviour concurrently.
Fragrance & Cosmetics
Nano-emulsification and one step extraction of essential oils and botanical actives. It works at low temperature, maintaining the volatile top notes that are lost in steam distillation or heat extraction.
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Support Type
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Details
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Warranty
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1-year parts & labor coverage
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Ongoing Support
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Lifetime technical support from assigned specialist
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Documentation
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Full technical package: drawings, manuals, certs, test records
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Remote Support
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Video-assisted troubleshooting within 24 hours
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Spare Parts
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Direct supply from manufacturer; no third-party markups
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FAT
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Available at Xi'an facility; travel coordination supported
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15+ years manufacturing ultrasonic processing equipment for pharmaceutical, chemical, and food industries across more than 40 countries.
What that means for your order:
Every unit is manufactured and tested to international compliance standards before shipment.
Certifications held:
Pre-shipment quality checks include:
All test records and certificates are included in the shipment documentation package.
Q: Can the machine be used for processing ethanol/other flammable solvents?
A: Yes - optional full explosion-proof setup. This includes generators with ATEX/IECEx rating, explosion-proof motor assemblies and pressurised inert-gas purged enclosures with rating for Zone 1/Zone 2 hazardous environments. In pharmaceutical manufacture it is used commonly for ethanol and hexane extraction.
Q: How is the temperature controlled during the extraction?
A: Process temperature is controlled using jacketed flow cells coupled to an external re-circulating chiller. A chiller actively extracts heat from the acoustic cavitation and maintains the bulk temperature within ±2°C of setpoint during the extraction cycle.
Q: What is the life of the ultrasonic horn?
A: A regular botanical extraction service typically runs for 3,000–8,000 operational hours before Ti-6Al-4V Grade 5 sonotrodes need to be inspected or replaced. The lifespan is decreased by high amplitude settings (>80%), abrasive slurries or extremely corrosive solvent solutions. We provide replacement sonotrodes directly and preserve dimensional records on all bespoke horn shapes.
Q: Can I scale from lab to production without losing extraction performance?
A: Yes. The scale-up is dependent on matching particular energy input (Ws/mL). We take the energy density that you measure in your lab unit and reproduce it in the industrial setup by varying the flow rate, amplitude and residence duration. This will keep the extraction kinetics constant, regardless of the volume.
Q: Will the titanium sonotrode contaminate my extract?
A: Titanium erosion under normal working conditions is insignificant and below detection limits for most analytical techniques. For pharmaceutical applications with severe metal impurity requirements (ICH Q3D), we provide zirconia ceramic probes as a drop-in replacement with no titanium contribution.
Q: Can I customise?
A: PLC control package, explosion-proof electrical components, dual-ultrasonic transducer heads, organic solvent recovery condenser, CIP cleaning system, automated discharge valve and unique flow cell shapes are standard customisation options. Full OEM/ODM design with your branding paperwork is allowed.
Tell us your feedstock, target compound, and current production volume for the ultrasound assisted extraction machine.
Contact us: info@biolandequip.com
2024-05-16
Pharmaceutical Company
The reactor is beautifully mirror-polished and fully complies with GMP requirements for the pharmaceutical industry. The performance is excellent! Overall, we are very satisfied! We also provided with some feedback on our process improvements, which we hope will be helpful.
2024-04-09
Laboratory
Excellent and professional service. Always reply our questions very fast. All reactors and chiller we received are good too.
2024-02-15
Research Institute
Quality is beyond our expectation actually. After we got the extraction equipment and started using it, the performance was beyond our expectation. Very easy to use and very efficient to run. Service always respond us very quickly. Was also very helpful to help us. Thanks Bioland team. Very happy to work with you.
2023-11-20
Biotech Company
We are happy about the new purchase as always. Equipment and services are both good.
2023-08-05
Instrument Lab
This is the second order with Bioland instrument and everything is good as the first dateText.
2023-05-12
Global Trading Partner
Bioland instrument team is very helpful and professional. The sales helped us select the right equipment for our application, and their logistics people handled the transportation and customs declaration for our shipment. All that saved us a lot of work.
