Xi'an Bioland's propolis extraction machine combines ultrasonic-assisted extraction, integrated dewaxing, and vacuum concentration into one GMP-compliant system. It isolates flavonoids and phenolic acids from raw bee propolis in 24–40 minutes at 40–60°C — protecting heat-sensitive bioactives while handling high wax content that defeats conventional soaking methods. SUS316L contact parts, PLC automation, and explosion-proof configuration are standard.
Raw propolis is difficult to process: up to 30% beeswax by weight, a resinous texture that clogs filters, and heat-sensitive flavonoids that degrade above 65°C. Standard maceration takes 3–4 weeks and loses bioactive yield to oxidation.
This system was engineered around those specific challenges:
|
Technology parameter
|
|||||
|
Model
|
BL-TN-C50L
|
BL-TN -C100L
|
BL-TN -C200L
|
BL-TN -C300L
|
BL-TN -C500L
|
|
Volume (L)
|
50
|
100
|
200
|
300
|
500
|
|
Evaporation capacity (kg/h)
|
20
|
50
|
70
|
100
|
200
|
|
Motor power(KW)
|
2.7
|
2.7
|
2.7
|
3.5
|
3.5
|
|
Steam consumption(kg/h)
|
25
|
60
|
90
|
120
|
250
|
|
System vacuum (MPa)
|
-0.085
|
-0.085
|
-0.085
|
-0.085
|
-0.085
|
|
Pressure of jacket(MPa)
|
0.09~0.3
|
0.09~0.3
|
0.09~0.3
|
0.09~0.3
|
0.09~0.3
|
|
Compressed air (MPa)
|
0.5~0.6
|
0.5~0.6
|
0.5~0.6
|
0.5~0.6
|
0.5~0.6
|
|
Evaporation temperature(°C)
|
60~100
|
60~100
|
60~100
|
60~100
|
60~100
|
| Component | Specification | Purpose |
|---|---|---|
| Contact surfaces | SUS316L, Ra ≤ 0.4μm mirror polish | Corrosion resistance; prevents resin adhesion |
| Outer jacket | SUS304 stainless steel | Thermal insulation and structural integrity |
| Weld inspection | Radiographic or dye-penetrant | Eliminates crevices and contamination risk |
| Pressure testing | 1.5× design pressure hydrostatic | Pre-shipment vessel integrity |
| Vacuum testing | −0.09 MPa hold, 24 hours | Confirms seal performance under operating vacuum |
| Motor & panel | Ex d II B T4 explosion-proof | Safe for ethanol processing environments |
All vessels are factory-tested before shipment. FAT (Factory Acceptance Test) available on request — includes live solvent recovery verification and dewaxing run.
Stage 1 — Ultrasonic Extraction
The propolis extraction machine loads raw propolis into the SUS316L extraction vessel. Ultrasonic transducers operate at 20–40 kHz, generating cavitation that mechanically ruptures the propolis matrix. Ethanol (or supercritical CO₂ for alcohol-free output) penetrates the broken structure, pulling out flavonoids and phenolic acids in 24–40 minutes.
Stage 2 — Winterization (Dewaxing)
Crude extract transfers into a jacketed winterization vessel, chilled to −10°C to −20°C. Beeswax, gums, and lipids crystallize and are removed through a plate-and-frame filter or centrifugal separator — filtration precision down to 0.45μm.
Stage 3 — Vacuum Concentration
A vacuum evaporator removes ethanol at temperatures below 60°C, concentrating the extract without heat damage. Recovered solvent (90–95% of input volume) is recirculated — reducing per-batch solvent cost and minimizing waste disposal.
Stage 4 — Final Product Handling
Output is a concentrated propolis paste or liquid. Depending on your formulation:
The PLC system logs each stage parameter — temperature, pressure, time — for GMP batch records.
Pharmaceutical Manufacturing
Produces propolis extracts with consistent total flavonoid content (>5% w/w), full wax removal, and traceable batch records. Suitable for throat sprays, softgels, lozenges, and tinctures in licensed GMP facilities.
Cosmetic & Skincare Formulation
Isolates antimicrobial phenolic acids with decolorization and deodorization — removing the dark pigment and sticky texture that make crude propolis unsuitable for serums and creams. Output integrates directly into standard cosmetic emulsification lines.
Functional Foods & Beverages
Water-soluble propolis (WSP) production for beverages, honey products, and dairy. The emulsification module or supercritical CO₂ pathway eliminates alcohol taste and precipitation — critical for clear-label beverage formulations.
Nutraceutical & Supplement Manufacturing
Standardized extract production for capsules, tablets, and powder blends — with consistent flavonoid assay results batch to batch.
Xi'an Bioland Instrument has manufactured extraction and separation equipment since 2009. Our propolis extraction systems are in operation across pharmaceutical manufacturers and functional food producers in Southeast Asia, Europe, and the Middle East.
Every order includes:
Q: How does the machine actually handle propolis's wax content — can't I just filter it out manually?
A: Manual filtration of raw propolis extract is impractical at scale: waxes re-emulsify at room temperature, blind standard filters quickly, and introduce inconsistency between batches. The winterization module chills the extract to −10°C to −20°C in a controlled jacketed vessel — waxes crystallize completely and are removed through 0.45μm precision filtration in a closed system. The result is reproducible across every batch.
Q: Can I get completely alcohol-free propolis extract from this machine?
A: Yes, through two pathways:
Q: What is the realistic solvent recovery rate, and what does that mean for my costs?
A: The secondary condenser loop recovers 90–95% of ethanol input per batch. For a facility running 10 batches per day with 20L ethanol per batch, that's approximately 190L recovered vs. 100L in a standard open-loop setup — a significant reduction in solvent procurement and waste disposal costs.
Q: How long does CIP cleaning actually take between batches?
A: Typically 30–45 minutes for a standard hot alkali wash cycle using the 360° rotary spray ball system. The CIP sequence is PLC-programmed — operators initiate it; the system runs automatically. No manual tank entry required.
Q: What documentation comes with the machine for GMP compliance?
A: Standard documentation package includes: material certificates for SUS316L contact parts, weld inspection records, hydrostatic and vacuum test reports, calibration certificates for temperature and pressure sensors, PLC software validation documentation, and CE/ISO certificates. IQ/OQ support documentation is available for pharmaceutical clients.
Q: We're a small manufacturer — is there a minimum batch size?
A: We manufacture systems from lab-scale (5–10L vessel) to full production lines (500L+). Configuration is customized to your batch size and output requirements. Contact us with your target daily throughput and we'll recommend the appropriate vessel size.
Tell us your target batch size, solvent preference, and output format for the propolis extraction machine.
Reach our team at info@biolandequip.com — quote within 24 hours.
2024-05-16
Pharmaceutical Company
The reactor is beautifully mirror-polished and fully complies with GMP requirements for the pharmaceutical industry. The performance is excellent! Overall, we are very satisfied! We also provided with some feedback on our process improvements, which we hope will be helpful.
2024-04-09
Laboratory
Excellent and professional service. Always reply our questions very fast. All reactors and chiller we received are good too.
2024-02-15
Research Institute
Quality is beyond our expectation actually. After we got the extraction equipment and started using it, the performance was beyond our expectation. Very easy to use and very efficient to run. Service always respond us very quickly. Was also very helpful to help us. Thanks Bioland team. Very happy to work with you.
2023-11-20
Biotech Company
We are happy about the new purchase as always. Equipment and services are both good.
2023-08-05
Instrument Lab
This is the second order with Bioland instrument and everything is good as the first dateText.
2023-05-12
Global Trading Partner
Bioland instrument team is very helpful and professional. The sales helped us select the right equipment for our application, and their logistics people handled the transportation and customs declaration for our shipment. All that saved us a lot of work.
