Xi'an Bioland Instrument Co., Ltd. has specialized in extraction and separation equipment manufacturing for over 15 years, providing industrial-grade herbal extraction units to the pharmaceutical, plant extraction, and functional ingredient industries. The system operates under low-temperature vacuum conditions at 40–60°C, improving yields by 50–500% compared to traditional processes. It supports multiple extraction modes including SD, UAE, and OSE, with integrated filtration and solvent recovery. Compliant with cGMP/FDA regulatory requirements and certified to CE, ISO, and ATEX, it serves customers worldwide.
Yield Improvement 50-500%
The technique improves mass transfer efficiency at the plant cell wall by precisely controlling the temperature, solvent polarity and agitation dynamics, instead of using open-tank percolation or simple maceration processes. Comparative measurement: Curcumin crude extraction yield increased from 1.2% to 4.8% (based on 95% ethanol/water system, 200L batch)
Low Temperature Vacuum Protection for Heat Sensitive Parts
The system is running at a complete vacuum and a stable 40–60ºC. The vacuum atmosphere can reduce boiling points of solvents by 20-30°C and can effectively prevent thermal degradation of thermally unstable substances such as flavonoids, alkaloids and terpenoids. Suitable for gentle extraction of high value components such as rosmarinic acid and paclitaxel.
Explosion-Proof Design — Safe & Compliant for Ethanol/Hexane Conditions
Full ATEX/IECEx Zone 1 configuration: explosion proof motors, intrinsically safe sensors, nitrogen inerting system. Meets highest safety standards for ethanol and hexane solvent processing environments, passes safety audits without changes.
Modular Integration — Reduced Operating Costs
Optional modules: solvent recovery unit (recovery rate ≥95%), spray ball CIP clean-in-place, automatic discharge valve. It doesn't require manual disassembly between batches, saving cross-contamination and labour cost by around 40%.
Step 1 — Feeding & Solvent Contact
Plant raw materials are loaded into the jacketed extraction vessel, and water, ethanol, or non-polar solvent is injected. A variable frequency drive (VFD) agitator (anchor/turbine/helical ribbon optional) generates controlled turbulence, allowing solvent to uniformly penetrate the material.
Step 2 — Dynamic Circulating Extraction
Unlike static soaking, the system continuously refreshes the solvent boundary layer at the cell wall, maintaining a high concentration gradient driving force. This mechanism shortens the single-batch extraction cycle from the traditional 8–12 hours to 2–4 hours.
Step 3 — Filtration & Solvent Recovery
The extract is separated from spent material through integrated filtration stages. The solvent recovery system removes residual solvent, outputting concentrated oleoresin or dry extract. Residual solvent can be controlled below 50 ppm, meeting ICH Q3C global regulatory requirements.
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Technology parameter
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Model
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BL-TN-C50L
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BL-TN -C100L
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BL-TN -C200L
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BL-TN -C300L
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BL-TN -C500L
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Volume (L)
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50
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100
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200
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300
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500
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Evaporation capacity (kg/h)
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20
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50
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70
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100
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200
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Motor power(KW)
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2.7
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2.7
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2.7
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3.5
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3.5
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Steam consumption(kg/h)
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25
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60
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90
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120
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250
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System vacuum (MPa)
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-0.085
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-0.085
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-0.085
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-0.085
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-0.085
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Pressure of jacket(MPa)
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0.09~0.3
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0.09~0.3
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0.09~0.3
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0.09~0.3
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0.09~0.3
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Compressed air (MPa)
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0.5~0.6
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0.5~0.6
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0.5~0.6
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0.5~0.6
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0.5~0.6
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Evaporation temperature(°C)
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60~100
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60~100
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60~100
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60~100
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60~100
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Wetted parts are made of SS316L, with internal surfaces electropolished to Ra < 0.4µm, eliminating microbial growth points and complying with ASME BPE bioprocessing standards.
The jacket design (dimpled or coil type) supports high heat transfer coefficients for rapid heating/cooling cycles. Seals use PTFE or Kalrez, compatible with both polar and non-polar multi-solvent systems with no swelling risk.
Material traceability reports (MTR) are available for all materials. Hydrostatic testing is performed per ASME VIII Div.1 (1.3× design pressure), with optional helium leak detection to verify vacuum integrity.
With over 15 years focused on herbal extraction unit, extraction and separation equipment manufacturing, Bioland's engineering team includes professional engineers in chemical machinery, pharmaceutical engineering, and automation control, with full-chain in-house R&D capability from process selection to equipment delivery.
Compared to equivalent imported equipment, Bioland offers the same level of GMP compliance, with delivery cycles shortened by 30–40%, and supports customized OEM/ODM services — flexibility that most European suppliers cannot provide.
Each project is assigned a dedicated engineer, with weekly photo or video progress updates during production. Goods are shipped only after your visual confirmation or completion of on-site FAT. Sea, rail, and air freight are supported, selected on demand.
Pharmaceutical API Production
Used for closed-loop extraction of high-purity active ingredients such as artemisinin and paclitaxel. Supports IQ/OQ/PQ validation documentation packages, directly compatible with FDA audit processes.
Standardized Nutrient Extraction
Large-scale processing of plant biomass to produce standardized materials such as 95% curcumin and ginsenosides. Residual solvent indicators meet USP/EP global market requirements.
Functional Cosmetic Ingredients
The vacuum low-temperature process protects the olfactory profile of volatile components such as rose essential oil and lavender absolute, inhibiting oxidative degradation of sensitive VOCs.
Food & Beverage and New Materials
Supports natural flavor extraction, natural pigment concentration, and food-grade functional ingredient processing, suitable for both food and industrial applications.
Each unit holds CE, ISO, UL, SGS, ATEX, and IEC certifications. Production and design follow GMP and FDA guidelines throughout.
Factory Acceptance Testing (FAT) is performed before dispatch, covering: agitation performance verification, heating/cooling loop testing, and control logic simulation. CIP efficiency is verified through riboflavin (Vitamin B2) spray coverage testing; surface passivation is confirmed through ferrocyanide testing.
Q: How are heat-sensitive plant components protected?
A: Vacuum operation can lower solvent boiling points by 20–30°C, allowing the system to complete extraction at temperatures as low as below 40°C, effectively protecting thermally unstable compounds such as flavonoids, terpenoids, and glycosides from high-temperature degradation.
Q: Can it be compatible with both ethanol and water-based solvents?
A: Yes. Seals are made of PTFE or Kalrez, with no swelling in either polar or non-polar solvent systems, supporting solvent switching without replacing sealing components.
Q: What explosion-proof rating does it achieve?
A: The system is certified to ATEX Zone 1 / IECEx, equipped with explosion-proof motors and a nitrogen inerting system, meeting the highest safety level requirements for ethanol or hexane processing environments.
Q: Does it support CIP cleaning between batches?
A: Yes. Fixed spray balls and automatic CIP programs are built in. Riboflavin spray testing verifies 100% internal surface coverage with zero residue risk.
Q: What certification documents can be provided?
A: CE, ISO, UL, SGS, ATEX, and IEC certifications; SS316L wetted parts MTR material traceability reports; hydrostatic test reports — available on request.
Q: Is custom development for specific plants or processes supported?
A: OEM/ODM services are supported. The engineering team can provide customized design solutions based on specific plant sources, solvent types, batch scale, and GMP facility layout. Preliminary engineering drawings are issued within 7 business days after project initiation.
To obtain a 48-hour custom quotation or free process solution matching for the herbal extraction unit, please send your requirements to: info@biolandequip.com
2024-05-16
Pharmaceutical Company
The reactor is beautifully mirror-polished and fully complies with GMP requirements for the pharmaceutical industry. The performance is excellent! Overall, we are very satisfied! We also provided with some feedback on our process improvements, which we hope will be helpful.
2024-04-09
Laboratory
Excellent and professional service. Always reply our questions very fast. All reactors and chiller we received are good too.
2024-02-15
Research Institute
Quality is beyond our expectation actually. After we got the extraction equipment and started using it, the performance was beyond our expectation. Very easy to use and very efficient to run. Service always respond us very quickly. Was also very helpful to help us. Thanks Bioland team. Very happy to work with you.
2023-11-20
Biotech Company
We are happy about the new purchase as always. Equipment and services are both good.
2023-08-05
Instrument Lab
This is the second order with Bioland instrument and everything is good as the first dateText.
2023-05-12
Global Trading Partner
Bioland instrument team is very helpful and professional. The sales helped us select the right equipment for our application, and their logistics people handled the transportation and customs declaration for our shipment. All that saved us a lot of work.
